[HTML][HTML] ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint
P Nghiem, PK Park, Y Kim, BN Desai… - Journal of Biological …, 2002 - ASBMB
ATR (ataxiatelangiectasia and Rad-3-related) is a protein kinase required for survival after
DNA damage. A critical role for ATR has been hypothesized to be the regulation of p53 and
other cell cycle checkpoints. ATR has been shown to phosphorylate p53 at Ser 15, and this
damage-induced phosphorylation is diminished by expression of a catalytically inactive
(ATR-kd) mutant. p53 function could not be examined directly in prior studies of ATR,
however, because p53 was mutant or because cells expressed the SV40 large T antigen …
DNA damage. A critical role for ATR has been hypothesized to be the regulation of p53 and
other cell cycle checkpoints. ATR has been shown to phosphorylate p53 at Ser 15, and this
damage-induced phosphorylation is diminished by expression of a catalytically inactive
(ATR-kd) mutant. p53 function could not be examined directly in prior studies of ATR,
however, because p53 was mutant or because cells expressed the SV40 large T antigen …