Regulation of the fibronectin receptor affinity by divalent cations.
J Gailit, E Ruoslahti - Journal of Biological Chemistry, 1988 - ASBMB
The cell surface receptor for fibronectin is a heterodimeric membrane protein that recognizes
an Arg-Gly-Asp sequence in fibronectin and that requires cations such as Mg2+ or Ca2+ for
binding to fibronectin. The divalent cation requirements of this receptor were analyzed by
measuring attachment of receptor liposomes to ligand-coated surfaces in the presence of
different cations. The most striking effect observed was produced by Mn2+, which increased
the binding of the receptor liposomes to fibronectin 2-3-fold over their binding in buffers …
an Arg-Gly-Asp sequence in fibronectin and that requires cations such as Mg2+ or Ca2+ for
binding to fibronectin. The divalent cation requirements of this receptor were analyzed by
measuring attachment of receptor liposomes to ligand-coated surfaces in the presence of
different cations. The most striking effect observed was produced by Mn2+, which increased
the binding of the receptor liposomes to fibronectin 2-3-fold over their binding in buffers …