Myocardial function with reduced expression of the sodium-calcium exchanger
MC Jordan, SA Henderson, T Han, MC Fishbein… - Journal of cardiac …, 2010 - Elsevier
BACKGROUND: The complete removal of the cardiac sodium-calcium exchanger (NCX1) is
associated with embryonic lethality, whereas its overexpression is linked to heart failure. To
determine whether or not a reduced expression of NCX1 is compatible with normal heart
structure and function, we studied 2 knockout (KO) mouse models with reduced levels of
NCX1: a heterozygous global KO (HG-KO) with a 50% level of NCX1 expression in all
myocytes, and a ventricular-specific KO (V-KO) with NCX1 expression in only 10% to 20% of …
associated with embryonic lethality, whereas its overexpression is linked to heart failure. To
determine whether or not a reduced expression of NCX1 is compatible with normal heart
structure and function, we studied 2 knockout (KO) mouse models with reduced levels of
NCX1: a heterozygous global KO (HG-KO) with a 50% level of NCX1 expression in all
myocytes, and a ventricular-specific KO (V-KO) with NCX1 expression in only 10% to 20% of …