[HTML][HTML] The L-type calcium channel in the heart: the beat goes on
I Bodi, G Mikala, SE Koch, SA Akhter… - The Journal of …, 2005 - Am Soc Clin Investig
I Bodi, G Mikala, SE Koch, SA Akhter, A Schwartz
The Journal of clinical investigation, 2005•Am Soc Clin InvestigSydney Ringer would be overwhelmed today by the implications of his simple experiment
performed over 120 years ago showing that the heart would not beat in the absence of
Ca2+. Fascination with the role of Ca2+ has proliferated into all aspects of our
understanding of normal cardiac function and the progression of heart disease, including
induction of cardiac hypertrophy, heart failure, and sudden death. This review examines the
role of Ca2+ and the L-type voltage-dependent Ca2+ channels in cardiac disease.
performed over 120 years ago showing that the heart would not beat in the absence of
Ca2+. Fascination with the role of Ca2+ has proliferated into all aspects of our
understanding of normal cardiac function and the progression of heart disease, including
induction of cardiac hypertrophy, heart failure, and sudden death. This review examines the
role of Ca2+ and the L-type voltage-dependent Ca2+ channels in cardiac disease.
Sydney Ringer would be overwhelmed today by the implications of his simple experiment performed over 120 years ago showing that the heart would not beat in the absence of Ca2+. Fascination with the role of Ca2+ has proliferated into all aspects of our understanding of normal cardiac function and the progression of heart disease, including induction of cardiac hypertrophy, heart failure, and sudden death. This review examines the role of Ca2+ and the L-type voltage-dependent Ca2+ channels in cardiac disease.
The Journal of Clinical Investigation