Cytochrome P450 epoxygenases and the soluble epoxide hydrolase are enzymes that
regulate the cellular content of bioactive epoxides such as the epoxyeicosatrienoic acids
derived from arachidonic acid. Epoxyeicosatrienoic acids are recognized as lipid mediators
that participate in vascular signaling processes such as the acute regulation of vascular tone
and the processes of inflammation and angiogenesis.