[HTML][HTML] X-linked inhibitor of apoptosis (XIAP) inhibits c-Jun N-terminal kinase 1 (JNK1) activation by transforming growth factor β1 (TGF-β1) through ubiquitin …
S Kaur, F Wang, M Venkatraman, M Arsura - Journal of Biological …, 2005 - ASBMB
Active NF-κB renders malignant hepatocytes refractory to the growth inhibitory and pro-
apoptotic properties of transforming growth factorβ1 (TGF-β1). NF-κB counteracts TGF-β1-
induced apoptosis through up-regulation of downstream target genes, such as XIAP and Bcl-
X L, which in turn inhibit the intrinsic pathway of apoptosis. In addition, induction of NF-κB by
TGF-β1 inhibits JNK signaling, thereby attenuating TGF-β1-induced cell death of normal
hepatocytes. However, the mechanism involved in the negative cross-talk between the NF …
apoptotic properties of transforming growth factorβ1 (TGF-β1). NF-κB counteracts TGF-β1-
induced apoptosis through up-regulation of downstream target genes, such as XIAP and Bcl-
X L, which in turn inhibit the intrinsic pathway of apoptosis. In addition, induction of NF-κB by
TGF-β1 inhibits JNK signaling, thereby attenuating TGF-β1-induced cell death of normal
hepatocytes. However, the mechanism involved in the negative cross-talk between the NF …