[HTML][HTML] Human mitochondrial thioredoxin: involvement in mitochondrial membrane potential and cell death
AE Damdimopoulos, A Miranda-Vizuete… - Journal of Biological …, 2002 - ASBMB
Thioredoxins (Trx) are a class of small multifunctional redox-active proteins found in all
organisms. Recently, we reported the cloning of a mitochondrial thioredoxin, Trx2, from rat
heart. To investigate the biological role of Trx2 we have isolated the human homologue,
hTrx2, and generated HEK-293 cells overexpressing Trx2 (HEK-Trx2). Here, we show that
HEK-Trx2 cells are more resistant toward etoposide. In addition, HEK-Trx2 are more
sensitive toward rotenone, an inhibitor of complex I of the respiratory chain. Finally …
organisms. Recently, we reported the cloning of a mitochondrial thioredoxin, Trx2, from rat
heart. To investigate the biological role of Trx2 we have isolated the human homologue,
hTrx2, and generated HEK-293 cells overexpressing Trx2 (HEK-Trx2). Here, we show that
HEK-Trx2 cells are more resistant toward etoposide. In addition, HEK-Trx2 are more
sensitive toward rotenone, an inhibitor of complex I of the respiratory chain. Finally …