[HTML][HTML] Insulin-like growth factor 1 differentially regulates estrogen receptor-dependent transcription at estrogen response element and AP-1 sites in breast cancer …
S Cascio, V Bartella, C Garofalo, A Russo… - Journal of biological …, 2007 - ASBMB
Cross-talk between insulin-like growth factor 1 (IGF-1) and estrogen receptor α (ER)
regulates gene expression in breast cancer cells, but the underlying mechanisms remain
unclear. Here, we studied how 17-β-estradiol (E2) and IGF-1 affect ER transcriptional
machinery in MCF-7 cells. E2 treatment stimulated ER loading on the estrogen response
element (ERE) in the pS2 promoter and on the AP-1 motif in the cyclin D1 promoter. On
ERE, similar amounts of liganded ER were found at 1–24-h time points, whereas on AP-1 …
regulates gene expression in breast cancer cells, but the underlying mechanisms remain
unclear. Here, we studied how 17-β-estradiol (E2) and IGF-1 affect ER transcriptional
machinery in MCF-7 cells. E2 treatment stimulated ER loading on the estrogen response
element (ERE) in the pS2 promoter and on the AP-1 motif in the cyclin D1 promoter. On
ERE, similar amounts of liganded ER were found at 1–24-h time points, whereas on AP-1 …