[HTML][HTML] Insulin receptor substrate-1 is the predominant signaling molecule activated by insulin-like growth factor-I, insulin, and interleukin-4 in estrogen receptor …

JG Jackson, MF White, D Yee - Journal of Biological Chemistry, 1998 - ASBMB
Because insulin-like growth factor-I (IGF-I), insulin, and interleukin-4 (IL-4) have known
biological effects in breast cancer cells and signal through insulin-receptor substrate (IRS)
adaptor proteins, we examined the expression and function of IRS-1 and IRS-2 in breast
tumors and cell lines. IRS-1 and IRS-2 were expressed by cell lines and primary breast
tumor specimens. IGF-I, insulin, and IL-4 treatment of MCF-7 and ZR-75, and IGF-I treatment
of T47-D breast cancer cells, resulted in much greater tyrosine phosphorylation of IRS-1 …