[HTML][HTML] Estrogen receptor α rapidly activates the IGF-1 receptor pathway
S Kahlert, S Nuedling, M Van Eickels, H Vetter… - Journal of Biological …, 2000 - ASBMB
Estrogen and insulin-like-growth factor 1 (IGF-1) are potent mitogenic stimuli that share
important properties in the control of cellular proliferation. However, the coupling between
the signaling cascades of estrogen receptors α and β and the IGF-1 receptor (IGF-1R) is
poorly understood. Therefore, we selectively transfected estrogen receptor α or β in COS7
and HEK293 cells, which contain IGF-1R. In presence of estrogen receptor α but not β, 17β-
estradiol (E2) rapidly induces phosphorylation of the IGF-1R and the extracellular signal …
important properties in the control of cellular proliferation. However, the coupling between
the signaling cascades of estrogen receptors α and β and the IGF-1 receptor (IGF-1R) is
poorly understood. Therefore, we selectively transfected estrogen receptor α or β in COS7
and HEK293 cells, which contain IGF-1R. In presence of estrogen receptor α but not β, 17β-
estradiol (E2) rapidly induces phosphorylation of the IGF-1R and the extracellular signal …