Glucagon: role in the hyperglycemia of diabetes mellitus
R Dobbs, H Sakurai, H Sasaki, G Faloona, I Valverde… - Science, 1975 - science.org
R Dobbs, H Sakurai, H Sasaki, G Faloona, I Valverde, D Baetens, L Orci, R Unger
Science, 1975•science.orgGlucagon suppression by somatostatin reduces or abolishes hyperglycemia in dogs made
insulin-deficient by somatostatin, alloxan, or total pancreatectomy. This suggests that the
development of severe diabetic hyperglycemia requires the presence of glucagon, whether
secreted by pancreatic or newly identified gastrointestinal A cells, as well as a lack of insulin.
Glucagon suppression could improve therapeutic glucoregulation in diabetes.
insulin-deficient by somatostatin, alloxan, or total pancreatectomy. This suggests that the
development of severe diabetic hyperglycemia requires the presence of glucagon, whether
secreted by pancreatic or newly identified gastrointestinal A cells, as well as a lack of insulin.
Glucagon suppression could improve therapeutic glucoregulation in diabetes.
Glucagon suppression by somatostatin reduces or abolishes hyperglycemia in dogs made insulin-deficient by somatostatin, alloxan, or total pancreatectomy. This suggests that the development of severe diabetic hyperglycemia requires the presence of glucagon, whether secreted by pancreatic or newly identified gastrointestinal A cells, as well as a lack of insulin. Glucagon suppression could improve therapeutic glucoregulation in diabetes.
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