Somatostatin: hypothalamic inhibitor of the endocrine pancreas
DJ Koerker, W Ruch, E Chideckel, J Palmer… - Science, 1974 - science.org
DJ Koerker, W Ruch, E Chideckel, J Palmer, CJ Goodner, J Ensinck, CC Gale
Science, 1974•science.orgSomatostatin, a hypothalamic peptide that inhibits the secretion of pituitary growth hormone,
inhibits basal insulin secretion in fasted cats and rats. In fasted baboons both basal and
arginine-stimulated secretion of insulin and glucagon are inhibited. Somatostatin appears to
act directly on the endocrine pancreas. The action is dose-related, rapid in onset, and
readily reversed.
inhibits basal insulin secretion in fasted cats and rats. In fasted baboons both basal and
arginine-stimulated secretion of insulin and glucagon are inhibited. Somatostatin appears to
act directly on the endocrine pancreas. The action is dose-related, rapid in onset, and
readily reversed.
Somatostatin, a hypothalamic peptide that inhibits the secretion of pituitary growth hormone, inhibits basal insulin secretion in fasted cats and rats. In fasted baboons both basal and arginine-stimulated secretion of insulin and glucagon are inhibited. Somatostatin appears to act directly on the endocrine pancreas. The action is dose-related, rapid in onset, and readily reversed.
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