[CITATION][C] An important role for glucagon in the regulation of glucose production in vivo
JE Liljenquist, JL Chiasson, AD Cherrington, U Keller… - Metabolism, 1976 - Elsevier
JE Liljenquist, JL Chiasson, AD Cherrington, U Keller, AS Jennings, JD Bomboy, WW Lacy
Metabolism, 1976•ElsevierIN the overnight fasted dog, basal hepatic glucose production increases when basal
glucagon levels are maintained during acute insulin deficiency and decreases when
glucagon is made deficient along with insulin. In postabsorptive insulin-dependent diabetic
man, a glucagon infusion at 5 ng/kg/min is associated with a prompt rise in hepatic glucose
production followed by a return to basal production despite continued glucagon infusion.
From these observations, it is concluded that in the postabsorptive state, glucagon is …
glucagon levels are maintained during acute insulin deficiency and decreases when
glucagon is made deficient along with insulin. In postabsorptive insulin-dependent diabetic
man, a glucagon infusion at 5 ng/kg/min is associated with a prompt rise in hepatic glucose
production followed by a return to basal production despite continued glucagon infusion.
From these observations, it is concluded that in the postabsorptive state, glucagon is …
I N the overnight fasted dog, basal hepatic glucose production increases when basal glucagon levels are maintained during acute insulin deficiency and decreases when glucagon is made deficient along with insulin. In postabsorptive insulin-dependent diabetic man, a glucagon infusion at 5 ng/kg/min is associated with a prompt rise in hepatic glucose production followed by a return to basal production despite continued glucagon infusion. From these observations, it is concluded that in the postabsorptive state, glucagon is important in maintaining basal glucose production, but physiologic elevations of glucagon cannot maintain increased production.
Elsevier