[HTML][HTML] NF-κB participates in the corticotropin-releasing, hormone-induced regulation of the pituitary proopiomelanocortin gene
KP Karalis, M Venihaki, J Zhao, LE van Vlerken… - Journal of Biological …, 2004 - ASBMB
Corticotropin-releasing hormone is a main regulator of mammalian stress response by
stimulating pituitary proopiomelanocortin (POMC) gene expression, and thus
adrenocorticotropic hormone (ACTH) secretion, which then causes glucocorticoid release
from the adrenal. In a recent study in the pituitary corticotroph cell line AtT20, oxidative stress
stimulated the activity of nuclear transcription factor B (NF-κB), whereas corticotropin-
releasing hormone (CRH) inhibited both the constitutive and the oxidative stress-induced NF …
stimulating pituitary proopiomelanocortin (POMC) gene expression, and thus
adrenocorticotropic hormone (ACTH) secretion, which then causes glucocorticoid release
from the adrenal. In a recent study in the pituitary corticotroph cell line AtT20, oxidative stress
stimulated the activity of nuclear transcription factor B (NF-κB), whereas corticotropin-
releasing hormone (CRH) inhibited both the constitutive and the oxidative stress-induced NF …