[HTML][HTML] Discordant effects of glucosamine on insulin-stimulated glucose metabolism and phosphatidylinositol 3-kinase activity
M Hawkins, M Hu, J Yu, H Eder, P Vuguin, L She… - Journal of Biological …, 1999 - ASBMB
The impact of increased GlcN availability on insulin-stimulated p85/p110
phosphatidylinositol 3-kinase (PI3K) activity in skeletal muscle was examined in relation to
GlcN-induced defects in peripheral insulin action. Primed continuous GlcN infusion (750
μmol/kg bolus; 30 μmol/kg· min) in conscious rats limited both maximal stimulation of muscle
PI3K by acute insulin (I)(1 unit/kg) bolus (I+ GlcN= 1.9-fold versussaline= 3.3-fold above
fasting levels; p< 0.01) and chronic activation of PI3K following 3-h euglycemic …
phosphatidylinositol 3-kinase (PI3K) activity in skeletal muscle was examined in relation to
GlcN-induced defects in peripheral insulin action. Primed continuous GlcN infusion (750
μmol/kg bolus; 30 μmol/kg· min) in conscious rats limited both maximal stimulation of muscle
PI3K by acute insulin (I)(1 unit/kg) bolus (I+ GlcN= 1.9-fold versussaline= 3.3-fold above
fasting levels; p< 0.01) and chronic activation of PI3K following 3-h euglycemic …