β-thalassaemia has served as a paradigm for chelation management for over three
decades, both in terms of defining the complications of transfusional iron overload, and
demonstrating the benefits of chelation therapy. Iron chelation therapy can be used to
reduce unacceptably high tissue iron levels, or to maintain current levels if these are
deemed safe, by matching the rate of transfused iron. Chelation therapy should be tailored
to the individual patient, based on the transfusional iron loading rate and the current level of …