[HTML][HTML] Retrocyclins kill bacilli and germinating spores of Bacillus anthracis and inactivate anthrax lethal toxin
W Wang, C Mulakala, SC Ward, G Jung… - Journal of biological …, 2006 - ASBMB
θ-defensins are cyclic octadecapeptides encoded by the modified α-defensin genes of
certain nonhuman primates. The recent demonstration that human α-defensins could
prevent deleterious effects of anthrax lethal toxin in vitro and in vivo led us to examine the
effects of θ-defensins on Bacillus anthracis (Sterne). We tested rhesus θ-defensins 1-3,
retrocyclins 1-3, and several analogues of RC-1. Low concentrations of θ-defensins not only
killed vegetative cells of B. anthracis (Sterne) and rendered their germinating spores …
certain nonhuman primates. The recent demonstration that human α-defensins could
prevent deleterious effects of anthrax lethal toxin in vitro and in vivo led us to examine the
effects of θ-defensins on Bacillus anthracis (Sterne). We tested rhesus θ-defensins 1-3,
retrocyclins 1-3, and several analogues of RC-1. Low concentrations of θ-defensins not only
killed vegetative cells of B. anthracis (Sterne) and rendered their germinating spores …