[HTML][HTML] Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxysphinganine: a novel category of bioactive 1-deoxysphingoid bases and 1 …
NC Zitomer, T Mitchell, KA Voss, GS Bondy… - Journal of biological …, 2009 - ASBMB
Fumonisin B 1 (FB 1) is a mycotoxin that inhibits ceramide synthases (CerS) and causes
kidney and liver toxicity and other disease. Inhibition of CerS by FB 1 increases sphinganine
(Sa), Sa 1-phosphate, and a previously unidentified metabolite. Analysis of the latter by
quadrupole-time-of-flight mass spectrometry assigned an m/z= 286.3123 in positive
ionization mode, consistent with the molecular formula for deoxysphinganine (C 18 H 40
NO). Comparison with a synthetic standard using liquid chromatography, electrospray …
kidney and liver toxicity and other disease. Inhibition of CerS by FB 1 increases sphinganine
(Sa), Sa 1-phosphate, and a previously unidentified metabolite. Analysis of the latter by
quadrupole-time-of-flight mass spectrometry assigned an m/z= 286.3123 in positive
ionization mode, consistent with the molecular formula for deoxysphinganine (C 18 H 40
NO). Comparison with a synthetic standard using liquid chromatography, electrospray …