[HTML][HTML] Neurofibromatosis type 1 (NF1) tumor suppressor, neurofibromin, regulates the neuronal differentiation of PC12 cells via its associating protein, CRMP-2
S Patrakitkomjorn, D Kobayashi, T Morikawa… - Journal of biological …, 2008 - ASBMB
Neurofibromatosis type 1 (NF1) tumor suppressor gene product, neurofibromin, functions in
part as a Ras-GAP, a negative regulator of Ras. Neurofibromin is implicated in the neuronal
abnormality of NF1 patients; however, the precise cellular function of neurofibromin has yet
to be clarified. Using proteomic strategies, we identified a set of neurofibromin-associating
cellular proteins, including axon regulator CRMP-2 (Collapsin response mediator protein-2).
CRMP-2 directly bound to the C-terminal domain of neurofibromin, and this association was …
part as a Ras-GAP, a negative regulator of Ras. Neurofibromin is implicated in the neuronal
abnormality of NF1 patients; however, the precise cellular function of neurofibromin has yet
to be clarified. Using proteomic strategies, we identified a set of neurofibromin-associating
cellular proteins, including axon regulator CRMP-2 (Collapsin response mediator protein-2).
CRMP-2 directly bound to the C-terminal domain of neurofibromin, and this association was …