Kip1 meets SKP2: new links in cell-cycle control
B Amati, J Vlach - Nature cell biology, 1999 - nature.com
B Amati, J Vlach
Nature cell biology, 1999•nature.comThe cyclin-dependent kinase inhibitor p27 Kip1 is degraded in a phosphorylation-and
ubiquitin-dependent way upon cell-cycle entry. p45 SKP2, the adaptor subunit of the
ubiquitin–protein ligase SCF SKP2, may mediate recognition and ubiquitination of
phosphorylated p27 Kip1.
ubiquitin-dependent way upon cell-cycle entry. p45 SKP2, the adaptor subunit of the
ubiquitin–protein ligase SCF SKP2, may mediate recognition and ubiquitination of
phosphorylated p27 Kip1.
Abstract
The cyclin-dependent kinase inhibitor p27 Kip1 is degraded in a phosphorylation-and ubiquitin-dependent way upon cell-cycle entry. p45 SKP2, the adaptor subunit of the ubiquitin–protein ligase SCF SKP2, may mediate recognition and ubiquitination of phosphorylated p27 Kip1.
nature.com