Natural history of neonatal herpes simplex virus infections in the acyclovir era

DW Kimberlin, CY Lin, RF Jacobs, DA Powell… - …, 2001 - publications.aap.org
Objective. During the 2 decades in which effective antiviral therapies have been available
for neonatal herpes simplex virus (HSV) disease, changes have been documented not only
in the outcomes of infected infants, but also in the natural history of the disease itself.
Numerous studies previously have reported that early institution of antiviral therapy is
beneficial to the outcome of the disease. The objective of this study was to provide an
update of neonatal HSV disease to identify means by which future improvements in the …