HIV-inducing factor in cervicovaginal secretions is associated with bacterial vaginosis in HIV-1-infected women
JA Cohn, FB Hashemi, M Camarca… - JAIDS Journal of …, 2005 - journals.lww.com
JA Cohn, FB Hashemi, M Camarca, F Kong, J Xu, SK Beckner, AA Kovacs, PS Reichelderfer…
JAIDS Journal of Acquired Immune Deficiency Syndromes, 2005•journals.lww.comObjective: Certain cervicovaginal lavage (CVL) fluid samples obtained from HIV-1-infected
and uninfected women stimulate in vitro HIV-1 replication. This activity, HIV-inducing factor
(HIF), changes when CVL fluid is heated. We sought to confirm a previous observation that
HIF was associated with bacterial vaginosis (BV). Methods: HIF was measured in unheated
and heated CVL fluid obtained from HIV-1-infected women and compared with the presence
of BV by Nugent scores, other genital tract conditions, and cervicovaginal HIV-1 shedding …
and uninfected women stimulate in vitro HIV-1 replication. This activity, HIV-inducing factor
(HIF), changes when CVL fluid is heated. We sought to confirm a previous observation that
HIF was associated with bacterial vaginosis (BV). Methods: HIF was measured in unheated
and heated CVL fluid obtained from HIV-1-infected women and compared with the presence
of BV by Nugent scores, other genital tract conditions, and cervicovaginal HIV-1 shedding …
Abstract
Objective:
Certain cervicovaginal lavage (CVL) fluid samples obtained from HIV-1-infected and uninfected women stimulate in vitro HIV-1 replication. This activity, HIV-inducing factor (HIF), changes when CVL fluid is heated. We sought to confirm a previous observation that HIF was associated with bacterial vaginosis (BV).
Methods:
HIF was measured in unheated and heated CVL fluid obtained from HIV-1-infected women and compared with the presence of BV by Nugent scores, other genital tract conditions, and cervicovaginal HIV-1 shedding.
Results:
Among the 295 women studied, 54% of CVL samples had HIF activity and 21% showed heat-stable HIF activity. In adjusted logistic regression, heat-stable HIF was associated with BV (odds ratio [OR]= 51.7, 95% confidence interval [CI]: 5.0, 530.7) and with intermediate flora (OR= 43.3, 95% CI: 3.6, 521.1); heat-labile HIF was not associated with BV. Neither heat-stable nor heat-labile HIF was associated with other cervicovaginal conditions nor, after controlling for plasma viral load, with genital tract HIV-1 shedding.
Conclusion:
We confirmed the association of HIF with BV and attribute it to the heat-stable component. Heat-stable activity is also associated, although less strongly, with intermediate vaginal flora. We propose that heat-stable HIF is a result of products of BV-associated bacteria.
Lippincott Williams & Wilkins