Toll-like receptor-3 as a target to enhance bioactivity of cancer immunotherapy

CF Nicodemus, L Wang, J Lucas, B Varghese… - American journal of …, 2010 - Elsevier
OBJECTIVE: The purpose of this study was to explore the potential of toll-like receptor-3
stimulation, with polyI: C12U (poly [l]. poly [C12, U]; rintatolimod [Ampligen; Hemispherx
Biopharma, Philadelphia, PA]) to enhance bioactivity of cancer immunotherapies. STUDY
DESIGN: Several models of immune activation were assessed with polyI: C12U at
concentrations that were achieved clinically. Dendritic cell maturation and antigen-specific
immune responses were evaluated in vitro and in a murine model. The potential for polyI …