[HTML][HTML] Essential role of neural Wiskott-Aldrich syndrome protein in neurite extension in PC12 cells and rat hippocampal primary culture cells
Y Banzai, H Miki, H Yamaguchi, T Takenawa - Journal of Biological …, 2000 - ASBMB
Neural Wiskott-Aldrich syndrome protein (N-WASP) is an actin-regulating protein that
induces filopodium formation downstream of Cdc42. It has been shown that filopodia
actively extend from the growth cone, a guidance apparatus located at the tip of neurites,
suggesting their role in neurite extension. Here we examined the possible involvement of N-
WASP in the neurite extension process. Since verprolin, cofilin homology andacidic region
(VCA) of N-WASP is known to be required for the activation of Arp2/3 complex that induces …
induces filopodium formation downstream of Cdc42. It has been shown that filopodia
actively extend from the growth cone, a guidance apparatus located at the tip of neurites,
suggesting their role in neurite extension. Here we examined the possible involvement of N-
WASP in the neurite extension process. Since verprolin, cofilin homology andacidic region
(VCA) of N-WASP is known to be required for the activation of Arp2/3 complex that induces …