[HTML][HTML] Prenatal, but not postnatal, inhibition of fibroblast growth factor receptor signaling causes emphysema
I Hokuto, AKT Perl, JA Whitsett - Journal of Biological Chemistry, 2003 - ASBMB
Although fibroblast growth factor (FGF) signaling is required for the formation of the lung in
the embryonic period, it is unclear whether FGF receptor activity influences lung
morphogenesis later in development. We generated transgenic mice expressing a soluble
FGF receptor (FGFR-HFc) under conditional control of the lung-specific surfactant protein C
promoter (SP-C-rtTA), to inhibit FGF activity at various times in late gestation and postnatally.
Although expression of FGFR-HFc early in development caused severe fetal lung …
the embryonic period, it is unclear whether FGF receptor activity influences lung
morphogenesis later in development. We generated transgenic mice expressing a soluble
FGF receptor (FGFR-HFc) under conditional control of the lung-specific surfactant protein C
promoter (SP-C-rtTA), to inhibit FGF activity at various times in late gestation and postnatally.
Although expression of FGFR-HFc early in development caused severe fetal lung …