[HTML][HTML] Stopping ras in its tracks
CJ Der, T Van Dyke - Cell, 2007 - cell.com
CJ Der, T Van Dyke
Cell, 2007•cell.comRas interacts with many downstream effectors that regulate complex cytoplasmic signaling
networks. In this issue, Gupta et al.(2007) use mouse models of Ras-mediated
tumorigenesis to show that the interaction of Ras with a single isoform of
phosphatidylinositol 3-kinase (PI3K), called p110α (PIK3CA), is critical for tumor formation.
This result will stimulate re-evaluation of pharmacological approaches to target Ras for
cancer treatment.
networks. In this issue, Gupta et al.(2007) use mouse models of Ras-mediated
tumorigenesis to show that the interaction of Ras with a single isoform of
phosphatidylinositol 3-kinase (PI3K), called p110α (PIK3CA), is critical for tumor formation.
This result will stimulate re-evaluation of pharmacological approaches to target Ras for
cancer treatment.
Ras interacts with many downstream effectors that regulate complex cytoplasmic signaling networks. In this issue, Gupta et al. (2007) use mouse models of Ras-mediated tumorigenesis to show that the interaction of Ras with a single isoform of phosphatidylinositol 3-kinase (PI3K), called p110α (PIK3CA), is critical for tumor formation. This result will stimulate re-evaluation of pharmacological approaches to target Ras for cancer treatment.
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