Platelet membrane early activation markers during prolonged storage
H Matsubayashi, J Weidner, CC Miraglia… - Thrombosis research, 1999 - Elsevier
The relationship between platelet aging and early markers of membrane activation have not
been defined clearly. Activation markers expressed during prolonged storage are similar if
not identical to those that appear after exposure to thrombin. Using flow cytometry, we
investigated platelet membrane expression of CD62P, CD63, and annexin V binding (ie,
loss of membrane asymmetry) in platelets stored for up to 11 days under standard blood
banking conditions. We compared five apheresis platelets to two random donor platelet …
been defined clearly. Activation markers expressed during prolonged storage are similar if
not identical to those that appear after exposure to thrombin. Using flow cytometry, we
investigated platelet membrane expression of CD62P, CD63, and annexin V binding (ie,
loss of membrane asymmetry) in platelets stored for up to 11 days under standard blood
banking conditions. We compared five apheresis platelets to two random donor platelet …