Fetal and neonatal alloimmune thrombocytopenia

C Kaplan - Women's Issues in Thrombosis and Hemostasis, 2002 - taylorfrancis.com
C Kaplan
Women's Issues in Thrombosis and Hemostasis, 2002taylorfrancis.com
INTRODUCTION Fetal-neonatal alloimmune thrombocytopenia (NAIT) results from maternal
alloimmunization during pregnancy against fetal platelet antigen inherited from the father
that the mother lacks. 1 NAIT is considered to be the counterpart of Rh haemolytic disease of
the newborn. In contrast to haemolytic disease of the newborn, NAIT may affect the first child.
Alloimmune thrombocytopenia is a transient passive disease in an otherwise healthy infant
but there is a risk of intracerebral haemorrhage during the whole severe thrombocytopenic …
INTRODUCTION Fetal-neonatal alloimmune thrombocytopenia (NAIT) results from maternal alloimmunization during pregnancy against fetal platelet antigen inherited from the father that the mother lacks.1 NAIT is considered to be the counterpart of Rh haemolytic disease of the newborn. In contrast to haemolytic disease of the newborn, NAIT may affect the first child. Alloimmune thrombocytopenia is a transient passive disease in an otherwise healthy infant but there is a risk of intracerebral haemorrhage during the whole severe thrombocytopenic period and, therefore, of neurological damage or death. The risk of lifethreatening haemorrhage necessitates a prompt diagnosis and effective therapy. Over the past few years remarkable progress has led to a better understanding of the natural history of NAIT, and this has led in turn to more precise diagnosis of the condition, the development of antenatal diagnosis and therapy, and better management of high-risk groups, which is still evolving.
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