Fetal and neonatal alloimmune thrombocytopenia: progress and ongoing debates
JB Bussel, A Primiani - Blood reviews, 2008 - Elsevier
Fetal and neonatal alloimmune thrombocytopenia (AIT) is a result of a parental
incompatibility of platelet-specific antigens and the transplacental passage of maternal
alloantibodies against the platelet antigen shared by the father and the fetus. It occurs in
approximately 1 in 1000 live births and is the most common cause of severe
thrombocytopenia in fetuses and term neonates. As screening programs are not routinely
performed, most affected fetuses are identified after birth when neonatal thrombocytopenia …
incompatibility of platelet-specific antigens and the transplacental passage of maternal
alloantibodies against the platelet antigen shared by the father and the fetus. It occurs in
approximately 1 in 1000 live births and is the most common cause of severe
thrombocytopenia in fetuses and term neonates. As screening programs are not routinely
performed, most affected fetuses are identified after birth when neonatal thrombocytopenia …