Endothelial nitric oxide synthase: a determinant of TNFα production by human monocytes/macrophages

H Mühl, J Pfeilschifter - Biochemical and biophysical research …, 2003 - Elsevier
H Mühl, J Pfeilschifter
Biochemical and biophysical research communications, 2003Elsevier
Until recently endothelial nitric oxide synthase (eNOS) has been associated exclusively with
physiological functions, particularly in the cardiovascular system. However, increasing
evidence has been accumulated that supports the concept for a role of eNOS in
pathophysiology. In particular, detection of eNOS protein and activity in human monocytes/
macrophages suggest an immunomodulatory role of this enzyme. Here, we review data that
promote the hypothesis that by enhancing TNFα production, eNOS activity should be …
Until recently endothelial nitric oxide synthase (eNOS) has been associated exclusively with physiological functions, particularly in the cardiovascular system. However, increasing evidence has been accumulated that supports the concept for a role of eNOS in pathophysiology. In particular, detection of eNOS protein and activity in human monocytes/macrophages suggest an immunomodulatory role of this enzyme. Here, we review data that promote the hypothesis that by enhancing TNFα production, eNOS activity should be regarded as a novel pro-inflammatory parameter in human monocytes/macrophages.
Elsevier