[HTML][HTML] PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation
M Holinstat, B Voss, ML Bilodeau… - Journal of Biological …, 2006 - ASBMB
Regulation of platelet activation plays a central role in hemostasis and pathophysiological
processes such as coronary artery disease. Thrombin is the most potent activator of
platelets. Human platelets express two thrombin receptors, PAR1 and PAR4, both of which
signal platelet activation. Evidence is lacking on the mechanism by which PAR1 and PAR4
may differentially signal platelet aggregation. Here we show that at the relatively high
concentration of agonist most likely found at the site of a local thrombus, dual inhibition of …
processes such as coronary artery disease. Thrombin is the most potent activator of
platelets. Human platelets express two thrombin receptors, PAR1 and PAR4, both of which
signal platelet activation. Evidence is lacking on the mechanism by which PAR1 and PAR4
may differentially signal platelet aggregation. Here we show that at the relatively high
concentration of agonist most likely found at the site of a local thrombus, dual inhibition of …