Acute treatment with tamoxifen reduces ischemic damage following middle cerebral artery occlusion
HK Kimelberg, PJ Feustel, Y Jin, J Paquette… - …, 2000 - journals.lww.com
Inhibitors of cell-swelling-activated anion channels, including the antiestrogenic compound
tamoxifen (TAM), have been shown to attenuate the increase in excitatory amino acids
(EAA) during ischemia. Since TAM enters the CNS we tested whether it provides protection
from damage due to reversible middle cerebral artery occlusion (rMCAo) in rats. TAM (5
mg/kg, iv) infused 25 min before ischemia, potently reduced the total volume of the infarct
from 328±34 mm 3 to 41±21 mm 3, a reduction of 87%, as measured by TTC staining. It was …
tamoxifen (TAM), have been shown to attenuate the increase in excitatory amino acids
(EAA) during ischemia. Since TAM enters the CNS we tested whether it provides protection
from damage due to reversible middle cerebral artery occlusion (rMCAo) in rats. TAM (5
mg/kg, iv) infused 25 min before ischemia, potently reduced the total volume of the infarct
from 328±34 mm 3 to 41±21 mm 3, a reduction of 87%, as measured by TTC staining. It was …