[HTML][HTML] Regulation of glucose-6-phosphatase gene expression by protein kinase Bα and the Forkhead transcription factor FKHR: evidence for insulin response unit …

D Schmoll, KS Walker, DR Alessi, R Grempler… - Journal of Biological …, 2000 - ASBMB
Glucose-6-phosphatase plays an important role in the regulation of hepatic glucose
production, and insulin suppresses glucose-6-phosphatase gene expression. Recent
studies indicate that protein kinase B and Forkhead proteins contribute to insulin-regulated
gene expression in the liver. Here, we examined the role of protein kinase B and Forkhead
proteins in mediating effects of insulin on glucose-6-phosphatasepromoter activity. Transient
transfection studies with reporter gene constructs demonstrate that insulin suppresses both …