[HTML][HTML] Assessment of the roles of mitogen-activated protein kinase, phosphatidylinositol 3-kinase, protein kinase B, and protein kinase C in insulin inhibition of cAMP …
JM Agati, D Yeagley, PG Quinn - Journal of Biological Chemistry, 1998 - ASBMB
Transcription of the phosphoenolpyruvate carboxykinase (PEPCK) gene is induced by
glucagon, acting through cAMP and protein kinase A, and this induction is inhibited by
insulin. Conflicting reports have suggested that insulin inhibits induction by cAMP by
activating the Ras/mitogen-activated protein kinase (MAPK) pathway or by activating the
phosphatidylinositol 3-kinase (PI3-kinase), but not MAPK, pathway. Insulin activated PI3-
kinase phosphorylates lipids that activate protein kinase B (PKB) and Ca 2+/diacylglycerol …
glucagon, acting through cAMP and protein kinase A, and this induction is inhibited by
insulin. Conflicting reports have suggested that insulin inhibits induction by cAMP by
activating the Ras/mitogen-activated protein kinase (MAPK) pathway or by activating the
phosphatidylinositol 3-kinase (PI3-kinase), but not MAPK, pathway. Insulin activated PI3-
kinase phosphorylates lipids that activate protein kinase B (PKB) and Ca 2+/diacylglycerol …