Type I juvenile diabetes mellitus is characterized by the infiltration of activated T
lymphocytes and monocytes into the islets of Langerhans of the pancreas, resulting in
inflammation and progressive destruction of the insulin-producing β cells. We hypothesized
that feeding nonobese diabetic (NOD) mice diets rich in polyphenols or vitamin A, both
known modulators of immune function, would decrease the autoimmune inflammatory
process associated with type I diabetes. NOD mice were fed a control diet (C) and diets …