Physiologically, left ventricular hypertrophy is primarily an adaptive remodeling process,
compensating for an increase in workload placed on the heart with the aim of minimizing
ventricular wall stress. Two contrasting models of adaptation may develop depending on the
patterns of stress imposed. Pressure overload, caused, for example, by hypertension or
aortic stenosis, requires the generation of greater intracavitary pressure during ventricular
contraction. This is achieved by arraying contractile protein units in parallel. Relatively, an …