[HTML][HTML] Control of cardiac growth and function by calcineurin signaling
RB Vega, R Bassel-Duby, EN Olson - Journal of Biological Chemistry, 2003 - ASBMB
The central role of calcium in the control of cardiac function is well established. The release
and reuptake of calcium by the sarcoplasmic reticulum (SR) 1 controls not only the
contraction of the cardiac myocyte but, ultimately, the heartbeat. However, the role of calcium
as a key second messenger in signal transduction pathways that control growth of the heart
has only recently been recognized. The calcium-dependent protein phosphatase
calcineurin, also called protein phosphatase 2B, is a critical transducer of calcium signals …
and reuptake of calcium by the sarcoplasmic reticulum (SR) 1 controls not only the
contraction of the cardiac myocyte but, ultimately, the heartbeat. However, the role of calcium
as a key second messenger in signal transduction pathways that control growth of the heart
has only recently been recognized. The calcium-dependent protein phosphatase
calcineurin, also called protein phosphatase 2B, is a critical transducer of calcium signals …