Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus …

T Matano, R Shibata, C Siemon, M Connors… - Journal of …, 1998 - Am Soc Microbiol
T Matano, R Shibata, C Siemon, M Connors, HC Lane, MA Martin
Journal of virology, 1998Am Soc Microbiol
Parenteral administration of a mouse anti-human CD8 monoclonal antibody (MAb) to rhesus
macaques resulted in a transient depletion of CD8+ cells in both the peripheral blood and
lymphoid tissues. When administered during primary chimeric simian/human
immunodeficiency virus infections, the CD8 MAb caused marked elevations of plasma and
cell-associated virus levels in both the peripheral blood and lymphoid tissues and led to
prolonged depletion of CD4 cells. Taken together, these results directly demonstrate that …
Abstract
Parenteral administration of a mouse anti-human CD8 monoclonal antibody (MAb) to rhesus macaques resulted in a transient depletion of CD8+ cells in both the peripheral blood and lymphoid tissues. When administered during primary chimeric simian/human immunodeficiency virus infections, the CD8 MAb caused marked elevations of plasma and cell-associated virus levels in both the peripheral blood and lymphoid tissues and led to prolonged depletion of CD4 cells. Taken together, these results directly demonstrate that CD8+ T lymphocytes are actively involved in controlling the acute phase of primate lentivirus infections.
American Society for Microbiology