Recent progress in the biology of airway dendritic cells and implications for understanding the regulation of asthmatic inflammation
H Hammad, BN Lambrecht - Journal of allergy and clinical immunology, 2006 - Elsevier
Dendritic cells (DCs) are crucial in determining the outcome of antigen encounter and
integrating signals derived from the antigen, its inflammatory context, and the host
environment into a signal that can be read by naive T cells in the lymphoid tissues and by
effector T cells in peripheral tissues. Airway DC subsets, however, induce different types of
immune responses, with plasmacytoid DCs promoting tolerance and myeloid DCs inducing
immunity. We also propose that airway DCs are not only crucial for sensitization to inhaled …
integrating signals derived from the antigen, its inflammatory context, and the host
environment into a signal that can be read by naive T cells in the lymphoid tissues and by
effector T cells in peripheral tissues. Airway DC subsets, however, induce different types of
immune responses, with plasmacytoid DCs promoting tolerance and myeloid DCs inducing
immunity. We also propose that airway DCs are not only crucial for sensitization to inhaled …