[HTML][HTML] Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells: evidence for an AMPK→ Rac1→ Akt→ endothelial nitric-oxide …
YC Levine, GK Li, T Michel - Journal of Biological Chemistry, 2007 - ASBMB
The endothelial isoform of nitric-oxide synthase (eNOS), a key determinant of vascular
homeostasis, is a calcium/calmodulin-dependent phosphoprotein regulated by diverse cell
surface receptors. Vascular endothelial growth factor (VEGF) and sphingosine 1-phosphate
(S1P) stimulate eNOS activity through Akt/phosphoinositide 3-kinase and calcium-
dependent pathways. AMP-activated protein kinase (AMPK) also activates eNOS in
endothelial cells; however, the molecular mechanisms linking agonist-mediated AMPK …
homeostasis, is a calcium/calmodulin-dependent phosphoprotein regulated by diverse cell
surface receptors. Vascular endothelial growth factor (VEGF) and sphingosine 1-phosphate
(S1P) stimulate eNOS activity through Akt/phosphoinositide 3-kinase and calcium-
dependent pathways. AMP-activated protein kinase (AMPK) also activates eNOS in
endothelial cells; however, the molecular mechanisms linking agonist-mediated AMPK …