[HTML][HTML] Involvement of acid β-glucosidase 1 in the salvage pathway of ceramide formation
Activation of protein kinase C (PKC) promotes the salvage pathway of ceramide formation,
and acid sphingomyelinase has been implicated, in part, in providing substrate for this
pathway (Zeidan, YH, and Hannun, YA (2007) J. Biol. Chem. 282, 11549–11561). In the
present study, we examined whether acid β-glucosidase 1 (GBA1), which hydrolyzes
glucosylceramide to form lysosomal ceramide, was involved in PKC-regulated formation of
ceramide from recycled sphingosine. Glucosylceramide levels declined after treatment of …
and acid sphingomyelinase has been implicated, in part, in providing substrate for this
pathway (Zeidan, YH, and Hannun, YA (2007) J. Biol. Chem. 282, 11549–11561). In the
present study, we examined whether acid β-glucosidase 1 (GBA1), which hydrolyzes
glucosylceramide to form lysosomal ceramide, was involved in PKC-regulated formation of
ceramide from recycled sphingosine. Glucosylceramide levels declined after treatment of …