[HTML][HTML] Tumor necrosis factor-α-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression …
JM Stephens, J Lee, PF Pilch - Journal of Biological Chemistry, 1997 - ASBMB
A number of studies have demonstrated that tumor necrosis factor-α (TNF-α) is associated
with profound insulin resistance in adipocytes and may also play a critical role in the insulin
resistance of obesity and non-insulin-dependent diabetes mellitus. Reports on the
mechanism of TNF-α action have been somewhat contradictory. GLUT4 down-regulation
has been implicated as a possible cause of insulin resistance as has been the reduced
kinase function of the insulin receptor. Here we examine the effects of tumor necrosis factor …
with profound insulin resistance in adipocytes and may also play a critical role in the insulin
resistance of obesity and non-insulin-dependent diabetes mellitus. Reports on the
mechanism of TNF-α action have been somewhat contradictory. GLUT4 down-regulation
has been implicated as a possible cause of insulin resistance as has been the reduced
kinase function of the insulin receptor. Here we examine the effects of tumor necrosis factor …