Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice
N Bijl, M Sokolović, C Vrins, M Langeveld… - Hepatology, 2009 - journals.lww.com
Nonalcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance, and
type 2 diabetes. The hyperinsulinemia that occurs as a consequence of insulin resistance is
thought to be an important contributor to the development of fatty liver. We have shown that
the iminosugar N-(5′-adamantane-1′-yl-methoxy)-pentyl-1-deoxynojirimycin (AMP-DNM),
an inhibitor of the enzyme glucosylceramide synthase, is a potent enhancer of insulin
signaling in rodent models for insulin resistance and type 2 diabetes. The present study was …
type 2 diabetes. The hyperinsulinemia that occurs as a consequence of insulin resistance is
thought to be an important contributor to the development of fatty liver. We have shown that
the iminosugar N-(5′-adamantane-1′-yl-methoxy)-pentyl-1-deoxynojirimycin (AMP-DNM),
an inhibitor of the enzyme glucosylceramide synthase, is a potent enhancer of insulin
signaling in rodent models for insulin resistance and type 2 diabetes. The present study was …