15-Epi-16-(para-fluorophenoxy)-lipoxin A4-methyl ester, a synthetic analogue of 15-epi-lipoxin A4, is protective in experimental ischemic acute renal failure
MO Leonard, K Hannan, MJ Burne… - Journal of the …, 2002 - journals.lww.com
Lipoxins are endogenous lipoxygenase-derived eicosanoids, generated during
inflammatory, hypersensitivity, and vascular events, that display vasodilatory,
antiinflammatory, and pro-resolution activity. Here, we evaluated the efficacy of 15-epi-16-
(para-fluorophenoxy)-lipoxin A 4-methyl ester (15-epi-16-(FPhO)-LXA 4-Me), a stable
synthetic analogue of aspirin-triggered 15-epi-lipoxin A 4 in ischemic acute renal failure
(ARF) in NIH Swiss mice. ARF was induced by 30-min crossclamping of renal pedicles and …
inflammatory, hypersensitivity, and vascular events, that display vasodilatory,
antiinflammatory, and pro-resolution activity. Here, we evaluated the efficacy of 15-epi-16-
(para-fluorophenoxy)-lipoxin A 4-methyl ester (15-epi-16-(FPhO)-LXA 4-Me), a stable
synthetic analogue of aspirin-triggered 15-epi-lipoxin A 4 in ischemic acute renal failure
(ARF) in NIH Swiss mice. ARF was induced by 30-min crossclamping of renal pedicles and …