IL-4 and IL-13 augment cytokine-and CD40-induced RANTES production by human renal tubular epithelial cells in vitro.
JG Deckers, S De Haij, FJ Van der Woude… - Journal of the …, 1998 - journals.lww.com
Local production of cytokines by infiltrating monocytes/macrophages and Th1 and Th2 cells
is of importance in renal allograft rejection. Activated Th1 cells can produce interleukin-2 (IL-
2), interferon-gamma (IFN-gamma), and tumor necrosis factor (TNF), whereas Th2 cells
produce IL-4 and IL-13, which inhibit Th1 cells. Furthermore, activated T cells express the
costimulatory molecule CD40-ligand. During renal allograft rejection, the chemokine
RANTES is detected in both infiltrating mononuclear cells and tubular epithelium. It has …
is of importance in renal allograft rejection. Activated Th1 cells can produce interleukin-2 (IL-
2), interferon-gamma (IFN-gamma), and tumor necrosis factor (TNF), whereas Th2 cells
produce IL-4 and IL-13, which inhibit Th1 cells. Furthermore, activated T cells express the
costimulatory molecule CD40-ligand. During renal allograft rejection, the chemokine
RANTES is detected in both infiltrating mononuclear cells and tubular epithelium. It has …