[HTML][HTML] Prevention of kidney ischemia/reperfusion-induced functional injury and JNK, p38, and MAPK kinase activation by remote ischemic pretreatment
KM Park, A Chen, JV Bonventre - Journal of Biological Chemistry, 2001 - ASBMB
MAPK activities, including JNK, p38, and ERK, are markedly enhanced after ischemia in
vivoand chemical anoxia in vitro. The relative extent of JNK, p38, or ERK activation has been
proposed to determine cell fate after injury. A mouse model was established in which prior
exposure to ischemia protected against a second ischemic insult imposed 8 or 15 days later.
In contrast to what was observed after 30 min of bilateral ischemia, when a second period of
ischemia of 30-or 35-min duration was imposed 8 days later, there was no subsequent …
vivoand chemical anoxia in vitro. The relative extent of JNK, p38, or ERK activation has been
proposed to determine cell fate after injury. A mouse model was established in which prior
exposure to ischemia protected against a second ischemic insult imposed 8 or 15 days later.
In contrast to what was observed after 30 min of bilateral ischemia, when a second period of
ischemia of 30-or 35-min duration was imposed 8 days later, there was no subsequent …