Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease

T Isakova, H Xie, W Yang, D Xie, AH Anderson… - Jama, 2011 - jamanetwork.com
Context A high level of the phosphate-regulating hormone fibroblast growth factor 23 (FGF-
23) is associated with mortality in patients with end-stage renal disease, but little is known
about its relationship with adverse outcomes in the much larger population of patients with
earlier stages of chronic kidney disease. Objective To evaluate FGF-23 as a risk factor for
adverse outcomes in patients with chronic kidney disease. Design, Setting, and Participants
A prospective study of 3879 participants with chronic kidney disease stages 2 through 4 who …