Recent progress in the biology and physiology of sirtuins
Nature, 2009•nature.com
The sirtuins are a highly conserved family of NAD+-dependent enzymes that regulate
lifespan in lower organisms. Recently, the mammalian sirtuins have been connected to an
ever widening circle of activities that encompass cellular stress resistance, genomic stability,
tumorigenesis and energy metabolism. Here we review the recent progress in sirtuin
biology, the role these proteins have in various age-related diseases and the tantalizing
notion that the activity of this family of enzymes somehow regulates how long we live.
lifespan in lower organisms. Recently, the mammalian sirtuins have been connected to an
ever widening circle of activities that encompass cellular stress resistance, genomic stability,
tumorigenesis and energy metabolism. Here we review the recent progress in sirtuin
biology, the role these proteins have in various age-related diseases and the tantalizing
notion that the activity of this family of enzymes somehow regulates how long we live.
Abstract
The sirtuins are a highly conserved family of NAD+-dependent enzymes that regulate lifespan in lower organisms. Recently, the mammalian sirtuins have been connected to an ever widening circle of activities that encompass cellular stress resistance, genomic stability, tumorigenesis and energy metabolism. Here we review the recent progress in sirtuin biology, the role these proteins have in various age-related diseases and the tantalizing notion that the activity of this family of enzymes somehow regulates how long we live.
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