[HTML][HTML] Identification of the potassium channel opener site on sulfonylurea receptors
I Uhde, A Toman, I Gross, C Schwanstecher… - Journal of Biological …, 1999 - ASBMB
Diversity of sulfonylurea receptor (SUR) subunits underlies tissue specific pharmacology of
K ATP channels, which represent critical regulators of electrical activity in numerous cells.
Notably, the neuronal/pancreatic β-cell receptor, SUR1, imparts high sensitivity to
hypoglycemic sulfonylureas (SUs; eg glibenclamide) and low to potassium channel openers
(KCOs; eg P1075), whereas the opposite drug sensitivities are conferred by cardiovascular
receptors, SUR2A and SUR2B. By exchanging domains between SUR1 and SUR2B, we …
K ATP channels, which represent critical regulators of electrical activity in numerous cells.
Notably, the neuronal/pancreatic β-cell receptor, SUR1, imparts high sensitivity to
hypoglycemic sulfonylureas (SUs; eg glibenclamide) and low to potassium channel openers
(KCOs; eg P1075), whereas the opposite drug sensitivities are conferred by cardiovascular
receptors, SUR2A and SUR2B. By exchanging domains between SUR1 and SUR2B, we …