Amino acid difference formula to help explain protein evolution
R Grantham - science, 1974 - science.org
R Grantham
science, 1974•science.orgA formula for difference between amino acids combines properties that correlate best with
protein residue substitution frequencies: composition, polarity, and molecular volume.
Substitution frequencies agree much better with overall chemical difference between
exchanging residues than with minimum base changes between their codons. Correlation
coefficients show that fixation of mutations between dissimilar amino acids is generally rare.
protein residue substitution frequencies: composition, polarity, and molecular volume.
Substitution frequencies agree much better with overall chemical difference between
exchanging residues than with minimum base changes between their codons. Correlation
coefficients show that fixation of mutations between dissimilar amino acids is generally rare.
A formula for difference between amino acids combines properties that correlate best with protein residue substitution frequencies: composition, polarity, and molecular volume. Substitution frequencies agree much better with overall chemical difference between exchanging residues than with minimum base changes between their codons. Correlation coefficients show that fixation of mutations between dissimilar amino acids is generally rare.
AAAS